2. Antibody-drug Conjugate/ADC Related JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. Antibody-Drug Conjugates (ADCs) EGFR
  4. Trastuzumab emtansine

Trastuzumab emtansine  (Synonyms: Ado-Trastuzumab emtansine; PRO132365; T-DM 1)

Cat. No.: HY-P9921 Purity: 99.40%
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Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (derivative of maytansine). Trastuzumab emtansine can be used for the research of advanced breast cancer.

For research use only. We do not sell to patients.

Trastuzumab emtansine Chemical Structure

Trastuzumab emtansine Chemical Structure

CAS No. : 1018448-65-1

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Based on 1 publication(s) in Google Scholar

Other Forms of Trastuzumab emtansine:

Trastuzumab emtansine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Trastuzumab emtansine

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Description

Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (derivative of maytansine). Trastuzumab emtansine can be used for the research of advanced breast cancer[1][2].

In Vitro

Trastuzumab emtansine (2 μg/mL; 3 d) significantly inhibits the proliferation of epithelial ovarian cancer (EOC) cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Trastuzumab emtansine Related Antibodies
In Vivo

Trastuzumab emtansine (15 mg/kg; i.v. three to five times weekly for 3 weeks) exhibits significantly anti-tumor effect in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CB-17/SCID mice (6 weeks) were injected with OVA10 cells[2]
Dosage: 15 mg/kg
Administration: I.v. three to five times weekly for 3 weeks
Result: Showed remarkable inhibition of tumor growth in mice and was well tolerated.
Clinical Trial
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Trastuzumab emtansine]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Purity: 99.74%

COA (291 KB)

Handling Instructions (2659 KB)
References
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Trastuzumab emtansine Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trastuzumab emtansine1018448-65-1Ado-Trastuzumab emtansine PRO132365 T-DM 1PRO132365PRO 132365PRO-132365Antibody-Drug Conjugates (ADCs)EGFRAntibody-Drug ConjugatesEpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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